A HOMOGENEOUS BIOSENSOR FOR CARBOHYDRATE ANTIGEN 153 DETECTION IN HUMAN SERUM BASED ON UPCONVERSION FLUORESCENCE RESONANCE ENERGY TRANSFER

A homogeneous biosensor for carbohydrate antigen 153 detection in human serum based on upconversion fluorescence resonance energy transfer

Quantitative determination of carbohydrate antigen 153 (CA153) in human serum plays an important role in early diagnosis of breast cancer.In this work, a highly sensitive and selective biosensor for CA153 detection was developed based on a fluorescent resonance energy transfer Hair Picks (FRET) strategy, in which near-infrared (NIR)-excitable upcon

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Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with short life expectancy and no effective therapy.We previously identified upregulated miR-124 in NSC-34-motor neurons (MNs) expressing human SOD1-G93A (mSOD1) and established its implication in mSOD1 MN degeneration and glial cell activation.When anti-miR-124-treated Spices mSOD1

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